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KMID : 0363219920300030362
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Korean Journal of Dermatology
1992 Volume.30 No. 3 p.362 ~ p.367
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Photoxic Reaction to Amiodarone as Studied with the Mouse Tail Technique and the Candida albicans Test
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Abstract
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We carried out the mouse tail technique and the Candida albicans test for the study of the phototoxic reaction to amiodarone. The mouse tail technique is based on the inflammatory response of mouse tails after systemic administration of the drug
and UVA
irradiation and the Candida albicans test is based on growh inhibition of Candida albicans.
In the mouse tail technique, following the administration of amiodarone and UVA irradia tion for 5 consecutive days, there was a significant increase (14%) in the relative water con tent as compared to other control groups. In the Candida
albicans
test,
UVA irradiation after pretreatment with amiodarone resulted in a clear Candida free zone around the disc. The results showed that amiodarone had a phototoxic potential and that both of the methods were a good screening test for demonstrating the
phototoxicity of a certain drug.
(Kor J Dermatol 1992 ; 30 (3) : 362-267)
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